Acuerdo de transparencia sobre el uso de animales en investigación

Introducción

La UMH está comprometida con la transparencia en experimentación animal y por ello se adhirió al Acuerdo de transparencia sobre el uso de animales en experimentación científica en España (abre en pestaña nueva) promovido por COSCE. Más información en https://cosce.org/acuerdo-de-transparencia/

A continuación, podrá encontrar la Declaración institucional de transparencia de la UMH sobre el uso de animales en investigación (abre en pestaña nueva).

Acuerdo de Transparencia sobre el uso de animales en experimentación científica en España, por la Confederación de Sociedades Científicas de España

Divulgación, formación y promoción de las 3R (UMH y externas)

Informes sobre el uso de animales con fines científicos en la UMH

Métodos Alternativos en Investigación Biomédica

Revisión de modelos no animales avanzados en investigación biomédica

La EURL ECVAM ha puesto en marcha una serie de estudios para revisar los modelos no animales disponibles y emergentes que se están utilizando para la investigación en siete áreas de enfermedades:

El objetivo es identificar y describir contextos de investigación específicos en los que se han dejado de lado los modelos animales en favor de técnicas novedosas sin animales que utilizan, por ejemplo, métodos in vitro basados en células humanas y tejidos artificiales o enfoques in silico que emplean la modelización y la simulación por ordenador.

Se espera que la comprensión y el intercambio de información sobre casos de éxito en el uso de modelos alternativos en la investigación biomédica faciliten y aceleren la transición hacia planteamientos sin animales.

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Avances en investigación biomédica gracias al uso de animales: producción científica

Producción científica del año 2024
  1. SUCNR1 regulates insulin secretion and glucose elevates the succinate response in people with prediabetes
  2. Multiple parallel cell lineages in the developing mammalian cerebral cortex
  3. Gene regulatory landscape of cerebral cortex folding
  4. SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer
  5. A multiomic atlas of the aging hippocampus reveals molecular changes in response to environmental enrichment
  6. The ion channel TRPM8 is a direct target of the immunosuppressant rapamycin in primary sensory neurons
  7. Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in Kras(G12D)-driven tumors
  8. Kainate receptors regulate synaptic integrity and plasticity by forming a complex with synaptic organizers in the cerebellum
  9. Overlapping role of synaptophysin and synaptogyrin family proteins in determining the small size of synaptic vesicles
  10. Essential role of p21(Waf1/Cip1) in the modulation of post-traumatic hippocampal Neural Stem Cells response
  11. ARID1A-BAF coordinates ZIC2 genomic occupancy for epithelial-to-mesenchymal transition in cranial neural crest specification
  12. Development of an efficient NUPR1 inhibitor with anticancer activity
  13. Piezo2 channels and tactile pain: an intriguing voltage connection
  14. 2-iodohexadecanal induces autophagy during goiter involution
  15. OCaR1 endows exocytic vesicles with autoregulatory competence by preventing uncontrolled Ca2+ release, exocytosis, and pancreatic tissue damage
  16. Transplantation of dorsal root ganglia overexpressing the NaChBac sodium channel improves locomotion after complete SCI
  17. Nrg1 intracellular signaling regulates the development of interhemispheric callosal axons in mice
  18. Disruption of the autism-associated Pcdh9 gene leads to transcriptional alterations, synapse overgrowth, and defective network activity in the CA1
  19. Cirrhosis-downregulated LSECtin can be retrieved by cytokines, shifts the TLR-induced LSECs secretome and correlates with the hepatic Th response
  20. Concentration of selected biogenic and risk elements in liver, kidneys and muscle of domestic rabbit and wild brown hare
  21. Fetal Cannabinoid Syndrome: Behavioral and Brain Alterations of the Offspring Exposed to Dronabinol during Gestation and Lactation
  22. Aging Deteriorates Blood Brain Barrier Function and Polarizes Adaptive T Cell Expansion Contributing to Neurocognitive Damage in Experimental Cirrhosis
  23. Preclinical Experimental Study on New Cervical Implant Design to Improve Peri-Implant Tissue Healing
  24. Hyperglucagonemia and glucagon hypersecretion in early type 2 diabetes result from multifaceted dysregulation of pancreatic mouse α-cells
  25. CXCL12 promotes the crossing of retinal ganglion cell axons at the optic chiasm
  26. Identification of Antimicrobial-Resistant Zoonotic Bacteria in Swine Production: Implications from the One Health Perspective
  27. Adolescent intermittent ethanol exposure decreases perineuronal nets in the hippocampus in a sex dependent manner: Modulation through pharmacological inhibition of RPTPβ/ζ
  28. A single dose of cocaine rewires the 3D genome structure of midbrain dopamine neurons
  29. Microdissection and Single-Cell Suspension of Neocortical Layers From Ferret Brain for Single-Cell Assays
  30. Mouse cortical organoids reveal key functions of p73 isoforms: TAp73 governs the establishment of the archetypical ventricular-like zones while DNp73 is central in the regulation of neural cell fate
  31. In Vivo Predictive Dissolution and Biopharmaceutic-Based In Silico Model to Explain Bioequivalence Results of Valsartan, a Biopharmaceutics Classification System Class IV Drug
  32. Self-experience of a negative event alters responses to others in similar states through prefrontal cortex CRF mechanisms
  33. Ocular surface information seen from the somatosensory thalamus and cortex
  34. Endoplasmic reticulum stress triggers unfolded protein response as an antiviral strategy of teleost erythrocytes
  35. Additive antinociceptive action of intrathecal anandamide reuptake inhibitor and morphine in the management of post-incisional pain in rats
  36. Enhancing In Vivo Electroporation Efficiency through Hyaluronidase: Insights into Plasmid Distribution and Optimization Strategies
  37. Proper Frequency of Perinatal Retinal Waves Is Essential for the Precise Wiring of Visual Axons in Nonimage-Forming Nuclei
  38. FrozONE: quick cell nucleus enrichment for comprehensive proteomics analysis of frozen tissues
  39. Specific targeting of the NRF2/β-TrCP axis promotes beneficial effects in NASH
  40. Cytomegalovirus infection of the fetal brain: intake of aspirin during pregnancy blunts neurodevelopmental pathogenesis in the offspring
  41. Pharmaceutical Compounding in Veterinary Medicine: Suspension of Itraconazole
  42. Factors affecting N-acetyl-β-D-glucosaminidase as an indicator for mastitis detection in dairy sheep
Producción científica del año 2023
  1. Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum suppresses interaction with familiar mice
  2. TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy
  3. Building thalamic neuronal networks during mouse development
  4. Cognitive Alterations in Addictive Disorders: A Translational Approach
  5. Role of TMEM100 in mechanically insensitive nociceptor un-silencing
  6. Cannabidiol regulates behavioral and brain alterations induced by spontaneous alcohol withdrawal
  7. Methods to Identify Cognitive Alterations from Animals to Humans: A Translational Approach
  8. Cannabidiol repairs behavioral and brain disturbances in a model of fetal alcohol spectrum disorder
  9. SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice
  10. Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
  11. A method for multiple sampling mouse sperm in vivo†
  12. MRI texture-based radiomics analysis for the identification of altered functional networks in alcoholic patients and animal models
  13. Long-Term Feeding of Dairy Goats with 40% Artichoke by-Product Silage Preserves Milk Yield, Nutritional Composition and Animal Health Status
  14. Monitoring Fine and Associative Motor Learning in Mice Using the Erasmus Ladder
  15. The outcome of boosting mitochondrial activity in alcohol-associated liver disease is organ-dependent
  16. The Contribution of TRPA1 to Corneal Thermosensitivity and Blink Regulation in Young and Aged Mice
  17. Mesoscale calcium imaging in vivo: evolution and contribution to developmental neuroscience
  18. Cyclosporine A Decreases Dryness-Induced Hyperexcitability of Corneal Cold-Sensitive Nerve Terminals
  19. Saturated fatty acid-enriched small extracellular vesicles mediate a crosstalk inducing liver inflammation and hepatocyte insulin resistance
  20. Regulation of Cortico-Thalamic JNK1/2 and ERK1/2 MAPKs and Apoptosis-Related Signaling Pathways in PDYN Gene-Deficient Mice Following Acute and Chronic Mild Stress
  21. Optimal Parameters to Milk Murciano-Granadina Goats in Mid and Low-Line Milking Parlours
  22. MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS
  23. FGF signaling promotes spreading of fat body precursors necessary for adult adipogenesis in Drosophila
  24. Unveiling behavioral and molecular neuroadaptations related to the antidepressant action of cannabidiol in the unpredictable chronic mild stress model
  25. Cell-specific vulnerability to metabolic failure: the crucial role of parvalbumin expressing neurons in creatine transporter deficiency
  26. Genetic and Phenotypic Parameters of Rabbit Individual Body Weight in the Preweaning Period
  27. Did the Addition of Olive Cakes Obtained by Different Methods of Oil Extraction in the Finishing Diet of Bísaro Pigs Affect the Volatile Compounds and Sensory Characteristics of Dry-Cured Loin and \”Cachaço\”?
  28. Natural and Pathological Aging Distinctively Impacts the Pheromone Detection System and Social Behavior
  29. Impact of inclusion of post-spermatic ejaculate fraction in boar seminal doses on sperm metabolism, quality, and interaction with uterine fluid
  30. Neuronal Cannabinoid CB(1) Receptors Suppress the Growth of Melanoma Brain Metastases by Inhibiting Glutamatergic Signalling
  31. Changes in Body Reserves, Non-Esterified Fatty Acids, and Leptin during the Reproductive Lifespan of the Rabbit Female
  32. Structural basis of envelope and phase intrinsic coupling modes in the cerebral cortex
  33. ReadEDTest: A tool to assess the readiness of in vitro test methods under development for identifying endocrine disruptors
  34. Increased alpha-synuclein and neuroinflammation in the substantia nigra triggered by systemic inflammation are reversed by targeted inhibition of the receptor for advanced glycation end products (RAGE)
  35. Effect of the Onset of Intramammary Infection on the Electrical Conductivity of Ewe’s Milk and Study of Various Algorithms for Its On-Line Detection
  36. Deep-brain stimulation of the human nucleus accumbens-medial septum enhances memory formation
  37. Lipid peroxidation and liver damage in double and simple common bile duct ligation models in male Sprague-Dawley rats
  38. Effect of environmental variance-based resilience selection on the gut metabolome of rabbits
  39. Selection for environmental variance shifted the gut microbiome composition driving animal resilience
  40. Umbilical cord mesenchymal stromal cells transplantation delays the onset of hyperglycemia in the RIP-B7.1 mouse model of experimental autoimmune diabetes through multiple immunosuppressive and anti-inflammatory responses
  41. Modulation of Caecal Microbiota and Metabolome Profile in Salmonella-Infected Broilers by Phage Therapy
  42. Long-term biophysical stability of nanodiamonds combined with lipid nanocarriers for non-viral gene delivery to the retina
  43. Extra centrosomes induce PIDD1-mediated inflammation and immunosurveillance
  44. BCL-XL Overexpression Protects Pancreatic β-Cells against Cytokine- and Palmitate-Induced Apoptosis
  45. β-Lactam TRPM8 Antagonists Derived from Phe-Phenylalaninol Conjugates: Structure-Activity Relationships and Antiallodynic Activity
Producción científica del año 2022
  1.  Abnormalities in Cortical GABAergic Interneurons of the Primary Motor Cortex Caused by Lis1 (Pafah1b1) Mutation Produce a Non-drastic Functional Phenotype
  2. Activation-induced chromatin reorganization in neurons depends on HDAC1 activity
  3. Acute and chronic effects of the organophosphate malathion on the pancreatic a and ß cell viability, cell structure, and voltage-gated K(+) currents
  4. Adhesion molecule Amigo2 is involved in the fasciculation process of the fasciculus retroflexus
  5. An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter ß-TrCP delivers anti-inflammatory responses in mouse liver
  6. Brain Network Allostasis after Chronic Alcohol Drinking Is Characterized by Functional Dedifferentiation and Narrowing
  7. Cannabidiol attenuates hypersensitivity and oxidative stress after traumatic spinal cord injury in rats
  8. Cannabinoid CB1 Receptor Involvement in the Actions of CBD on Anxiety and Coping Behaviors in Mice
  9. CBD-mediated regulation of heroin withdrawal-induced behavioural and molecular changes in mice
  10. CBP Is Required for Establishing Adaptive Gene Programs in the Adult Mouse Brain
  11. Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease
  12. Comparative evaluation of two collagen-based biomaterials with different compositions used for bone graft: An experimental animal study
  13. Don’t Let It Get Under Your Skin! – Vaccination Protects the Skin Barrier of Common Carp From Disruption Caused by Cyprinid Herpesvirus 3
  14. G protein-coupled estrogen receptor activation by bisphenol-A disrupts the protection from apoptosis conferred by the estrogen receptors ERa and ERß in pancreatic beta cells
  15. Genetic Analyses of Rabbit Survival and Individual Birth Weight
  16. Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy
  17. Gli2-Mediated Shh Signaling Is Required for Thalamocortical Projection Guidance
  18. How modular protein nanoparticles may expand the ability of subunit anti-viral vaccines: The spring viremia carp virus (SVCV) case
  19. Human Omental Mesothelial Cells Impart an Immunomodulatory Landscape Impeding B- and T-Cell Activation
  20. Immunological insights into the resistance of Nile tilapia strains to an infection with tilapia lake virus
  21. Impaired macroglial development and axonal conductivity contributes to the neuropathology of DYRK1A-related intellectual disability syndrome
  22. In Vitro and In Vivo Pharmacological Characterization of a Novel TRPM8 Inhibitor Chemotype Identified by Small-Scale Preclinical Screening
  23. In Vitro Assays to Identify Metabolism-Disrupting Chemicals with Diabetogenic Activity in a Human Pancreatic ß-Cell Model
  24. Input-dependent segregation of visual and somatosensory circuits in the mouse superior colliculus
  25. Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation
  26. miR-137 and miR-122, two outer subventricular zone non-coding RNAs, regulate basal progenitor expansion and neuronal differentiation
  27. Multimodal cues displayed by submissive rats promote prosocial choices by dominants
  28. Neuropathic pain caused by miswiring and abnormal end organ targeting
  29. Nootropic effects of LSD: Behavioral, molecular and computational evidence
  30. Open-source, Python-based, hardware and software for controlling behavioural neuroscience experiments
  31. Paneth Cells Regulate Lymphangiogenesis under Control of Microbial Signals during Experimental Portal Hypertension
  32. Preconception exposure to malathion and glucose homeostasis in rats: Effects on dams during pregnancy and post-term periods, and on their progeny
  33. Properties of the epileptiform activity in the cingulate cortex of a mouse model of LIS1 dysfunction
  34. Quality and Functional Parameters of Fermented Milk Obtained from Goat Milk Fed with Broccoli and Artichoke Plant By-Products
  35. Secondary loss of miR-3607 reduced cortical progenitor amplification during rodent evolution
  36. Serum angiotensin-converting enzyme 2 as a potential biomarker for SARS-CoV-2 infection and vaccine efficacy
  37. Specific contribution of Reelin expressed by Cajal-Retzius cells or GABAergic interneurons to cortical lamination
  38. Spontaneous Thalamic Activity Modulates the Cortical Innervation of the Primary Visual Nucleus of the Thalamus
  39. The Effects of Aging on Male Mouse Pancreatic ß-Cell Function Involve Multiple Events in the Regulation of Secretion: Influence of Insulin Sensitivity
  40. TRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraine
  41. Uncoupling axon guidance and neuronal migration in Robo3-deficient inferior olivary neurons
  42. ß-Lactam TRPM8 Antagonist RGM8-51 Displays Antinociceptive Activity in Different Animal Models
Producción científica del año 2021
  1. Non-productive angiogenesis disassembles Aß plaque-associated blood vessels
  2. Pointing Out Some Issues Regarding Reproduction Management in Murciano-Granadina Goats
  3. Unilateral Corneal Insult Also Alters Sensory Nerve Activity in the Contralateral Eye
  4. Sublayer- and cell-type-specific neurodegenerative transcriptional trajectories in hippocampal sclerosis
  5. Relationship between Prenatal Characteristics and Body Condition and Endocrine Profile in Rabbits
  6. Cannabidiol Modulates Behavioural and Gene Expression Alterations Induced by Spontaneous Cocaine Withdrawal
  7. Immunomodulatory Lectin-like Peptides for Fish Erythrocytes-Targeting as Potential Antiviral Drug Delivery Platforms
  8. Development of a Prodrug of Camptothecin for Enhanced Treatment of Glioblastoma Multiforme
  9. Cannabidiol and Sertraline Regulate Behavioral and Brain Gene Expression Alterations in an Animal Model of PTSD
  10. Wnt1 Role in the Development of the Habenula and the Fasciculus Retroflexus
  11. Antiviral Function of NKEF against VHSV in Rainbow Trout
  12. Increased P2×2 receptors induced by amyloid-ß peptide participates in the neurotoxicity in alzheimer’s disease
  13. Temporal Dynamics and Neuronal Specificity of Grin3a Expression in the Mouse Forebrain
  14. Development of the hypersecretory phenotype in the population of adrenal chromaffin cells from prehypertensive SHRs
  15. Automatic Prestimulation on Dairy Goats: Milking Efficiency and Teat-End Status
  16. Tangential Intrahypothalamic Migration of the Mouse Ventral Premamillary Nucleus and Fgf8 Signaling
  17. Sodium Channel Blockers Modulate Abnormal Activity of Regenerating Nociceptive Corneal Nerves After Surgical Lesion
  18. Phenylalanine-Derived ß-Lactam TRPM8 Modulators. Configuration Effect on the Antagonist Activity
  19. Effect of Vacuum Level and Pulsation Parameters on Milking Efficiency and Animal Welfare of Murciano-Granadina Goats Milked in Mid-Line and Low-Line Milking Machines
  20. Expression of the cold thermoreceptor TRPM8 in rodent brain thermoregulatory circuits
  21. Ventricular Fibrosis and Coronary Remodeling Following Short-Term Exposure of Healthy and Malnourished Mice to Bisphenol A
  22. Effects of a high-fat diet and global aryl hydrocarbon receptor deficiency on energy balance and liver retinoid status in male Sprague-Dawley rats
  23. Functional Interactions between Entorhinal Cortical Pathways Modulate Theta Activity in the Hippocampus
  24. Bone toxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the retinoid system: A causality analysis anchored in osteoblast gene expression and mouse data
  25. Body-fat sensor triggers ribosome maturation in the steroidogenic gland to initiate sexual maturation in Drosophila
  26. Induction of foxp3 during the Crosstalk between Antigen Presenting Like-Cells MHCII(+)CD83(+) and Splenocytes CD4(+)IgM(-) in Rainbow Trout
  27. Delta Opioid Receptor in Astrocytes Contributes to Neuropathic Cold Pain and Analgesic Tolerance in Female Mice
  28. DD04107-Derived neuronal exocytosis inhibitor peptides: Evidences for synaptotagmin-1 as a putative target
  29. Cannabidiol prevents priming- and stress-induced reinstatement of the conditioned place preference induced by cocaine in mice
  30. Terminal Crossbreeding of Murciano-Granadina Goats to Boer Bucks: Effects on Reproductive Performance of Goats and Growth of Kids in Artificial Rearing
  31. Role of aryl hydrocarbon receptor (AHR) in overall retinoid metabolism: Response comparisons to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure between wild-type and AHR knockout mice
  32. Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
  33. Endocrine, metabolic and apical effects of in utero and lactational exposure to non-dioxin-like 2,2′,3,4,4′,5,5′-heptachlorobiphenyl (PCB 180): A postnatal follow-up study in rats
  34. A unique bipartite Polycomb signature regulates stimulus-response transcription during development
  35. Bacteroides uniformis combined with fiber amplifies metabolic and immune benefits in obese mice
  36. The administration of sertraline plus naltrexone reduces ethanol consumption and motivation in a long-lasting animal model of post-traumatic stress disorder
  37. Neuroimaging reveals functionally distinct neuronal networks associated with high-level alcohol consumption in two genetic rat models
  38. Selection for environmental variance of litter size in rabbits involves genes in pathways controlling animal resilience
  39. Pairing Binge Drinking and a High-Fat Diet in Adolescence Modulates the Inflammatory Effects of Subsequent Alcohol Consumption in Mice
  40. USH2A is a Meissner’s corpuscle protein necessary for normal vibration sensing in mice and humans
  41. Pilot RNAi Screen in Drosophila Neural Stem Cell Lineages to Identify Novel Tumor Suppressor Genes Involved in Asymmetric Cell Division
  42. CDK11 Promotes Cytokine-Induced Apoptosis in Pancreatic Beta Cells Independently of Glucose Concentration and Is Regulated by Inflammation in the NOD Mouse Model
  43. The muscle-relaxing C-terminal peptide from troponin I populates a nascent helix, facilitating binding to tropomyosin with a potent therapeutic effect
  44. Transplantation of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium in a Swine Model of Geographic Atrophy
  45. Lactose-Gated Mesoporous Silica Particles for Intestinal Controlled Delivery of Essential Oil Components: An In Vitro and In Vivo Study
  46. Eremantholide C from aerial parts of Lychnophora trichocarpha, as drug candidate: fraction absorbed prediction in humans and BCS permeability class determination
  47. The second-generation antipsychotic drug aripiprazole modulates the serotonergic system in pancreatic islets and induces beta cell dysfunction in female mice
  48. Visual Disfunction due to the Selective Effect of Glutamate Agonists on Retinal Cells
  49. Effect of Postbiotic Based on Lactic Acid Bacteria on Semen Quality and Health of Male Rabbits
  50. Fatty Acid Profile of Blood Plasma at Mating and Early Gestation in Rabbit
  51. Respiratory disturbances and high risk of sudden death in the neonatal connexin-36 knockout mouse
  52. Update on the Inactivation Procedures for the Vaccine Development Prospects of a New Highly Virulent RGNNV Isolate
  53. Sphingolipid extracts enhance gene delivery of cationic lipid vesicles into retina and brain
  54. Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Brain Levels of Drug in Rat
  55. A differential equation based modelling approach to predict supersaturation and in vivo absorption from in vitro dissolution-absorption system (idas2) data
  56. Diversity of microorganisms in Hyalomma aegyptium collected from spur-thighed tortoise (Testudo graeca) in North Africa and Anatolia
  57. Modulation of the Tissue Expression Pattern of Zebrafish CRP-Like Molecules Suggests a Relevant Antiviral Role in Fish Skin
Producción científica del año 2020
  1. Low-dimensional dynamics for working memory and time encoding
  2. Piezo2 Mediates Low-Threshold Mechanically Evoked Pain in the Cornea
  3. Tau phosphorylation by glycogen synthase kinase 3ß modulates enzyme acetylcholinesterase expression
  4. Cannabidiol Modulates Behavioural and Gene Expression Alterations Induced by Spontaneous Cocaine Withdrawal
  5. Adaptive short-term associative conditioning in the pancreatic ß-cell
  6. Highly functionalized ß-lactams and 2-ketopiperazines as TRPM8 antagonists with antiallodynic activity
  7. Programming effects of peripubertal stress on spatial learning
  8. Neuronal tangential migration from Nkx2.1-positive hypothalamus
  9. Effects of the technique and drill design used during the osteotomy on the thermal and histological stimulation
  10. The effect of different sample collection methods on rabbit blood parameters
  11. Protective role of neuronal and lymphoid cannabinoid CB(2) receptors in neuropathic pain
  12. Topical treatment with a mu opioid receptor agonist alleviates corneal allodynia and corneal nerve sensitization in mice
  13. Liver Sinusoidal Endothelial Cells Contribute to Hepatic Antigen-Presenting Cell Function and Th17 Expansion in Cirrhosis
  14. Combined intramuscular and intraspinal transplant of bone marrow cells improves neuromuscular function in the SOD1(G93A) mice
  15. Identification of functional mutations associated with environmental variance of litter size in rabbits
  16. Surfactant-Triggered Molecular Gate Tested on Different Mesoporous Silica Supports for Gastrointestinal Controlled Delivery
  17. Functional Heterogeneity of Mouse and Human Brain OPCs: Relevance for Preclinical Studies in Multiple Sclerosis
  18. Surgical Induction of Endometriosis in Female Mice
  19. Repression of Irs2 by let-7 miRNAs is essential for homeostasis of the telencephalic neuroepithelium
  20. Correlated Response to Selection for Litter Size Residual Variability in Rabbits’ Body Condition
  21. Long-Term Feeding of Dairy Goats with Broccoli By-Product and Artichoke Plant Silages: Milk Yield, Quality and Composition
  22. Short-Term Effect of the Inclusion of Silage Artichoke By-Products in Diets of Dairy Goats on Milk Quality
  23. Can changes in implant macrogeometry accelerate the osseointegration process?: An in vivo experimental biomechanical and histological evaluations
  24. Dysbiosis in marine aquaculture revealed through microbiome analysis: reverse ecology for environmental sustainability
  25. Layer 2/3 Pyramidal Neurons of the Mouse Granular Retrosplenial Cortex and Their Innervation by Cortico-Cortical Axons
  26. Early Stimulation of TREK Channel Transcription and Activity Induced by Oxaliplatin-Dependent Cytosolic Acidification
  27. The beneficial effect of clove essential oil and its major component, eugenol, on erectile function in diabetic rats
  28. Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks
  29. Composition, Mineral and Fatty Acid Profiles of Milk from Goats Fed with Different Proportions of Broccoli and Artichoke Plant By-Products
  30. KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain
  31. Transient Hypothyroidism During Lactation Alters the Development of the Corpus Callosum in Rats. An in vivo Magnetic Resonance Image and Electron Microscopy Study
  32. Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions
  33. The Beneficial Effects of Lippia Citriodora Extract on Diet-Induced Obesity in Mice Are Associated with Modulation in the Gut Microbiota Composition
  34. Bisphenol-A exposure during pregnancy alters pancreatic ß-cell division and mass in male mice offspring: A role for ERß
  35. A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA(1)), UCM-05194, Shows Efficacy in Neuropathic Pain Amelioration
  36. Inflammatory Correlated Response in Two Lines of Rabbit Selected Divergently for Litter Size Environmental Variability
  37. Freezing Displayed by Others Is a Learned Cue of Danger Resulting from Co-experiencing Own Freezing and Shock
  38. USH2A is a Meissner’s corpuscle protein necessary for normal vibration sensing in mice and humans
  39. Chronic alcohol consumption alters extracellular space geometry and transmitter diffusion in the brain
  40. The prebiotic properties of Hibiscus sabdariffa extract contribute to the beneficial effects in diet-induced obesity in mice
  41. Shape perception via a high-channel-count neuroprosthesis in monkey visual cortex
  42. Zebrafish C-reactive protein isoforms inhibit SVCV replication by blocking autophagy through interactions with cell membrane cholesterol
  43. Transcriptomic Analysis Reveals the Wound Healing Activity of Mussel Myticin C
  44. Effect of Common Excipients on Intestinal Drug Absorption in Wistar Rats
  45. Segmental-Dependent Solubility and Permeability as Key Factors Guiding Controlled Release Drug Product Development
  46. SGK1.1 Reduces Kainic Acid-Induced Seizure Severity and Leads to Rapid Termination of Seizures
  47. Effect of thickener on disintegration, dissolution and permeability of common drug products for elderly patients
  48. Brain Angiogenesis Induced by Nonviral Gene Therapy with Potential Therapeutic Benefits for Central Nervous System Diseases
  49. Netrin-1/DCC Signaling Differentially Regulates the Migration of Pax7, Nkx6.1, Irx2, Otp, and Otx2 Cell Populations in the Developing Interpeduncular Nucleus
Producción científica del año 2019
  1. The centrosome protein AKNA regulates neurogenesis via microtubule organization
  2. Non-invasive MRI windows to neuroinflammation
  3. The Immunosuppressant Macrolide Tacrolimus Activates Cold-Sensing TRPM8 Channels
  4. Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma
  5. The Amniote Oculomotor Complex
  6. Immediate and deferred epigenomic signatures of in vivo neuronal activation in mouse hippocampus“
  7. Hydroxycholesterol binds and enhances the anti-viral activities of zebrafish monomeric c-reactive protein isoforms
  8. CBP and SRF co-regulate dendritic growth and synaptic maturation
  9. CBP/p300 in brain development and plasticity: disentangling the KAT’s cradle
  10. Cannabidiol does not display drug abuse potential in mice behavior
  11. FXR modulates the gut-vascular barrier by regulating the entry sites for bacterial translocation in experimental cirrhosis
  12. Rag1 immunodeficiency-induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidative stress
  13. Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models
  14. O-hexyl O-2,5-dichlorophenyl phosphoramidate as a substrate for domestic and sea bird serum A-esterases: Hydrolysis levels, Cu(2+)- and Zn(2+)-dependence and stereoselectivity
  15. A Retino-retinal Projection Guided by Unc5c Emerged in Species with Retinal Waves
  16. Microgrooves and Microrugosities in Titanium Implant Surfaces: An In Vitro and In Vivo Evaluation
  17. Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits
  18. Extensive branching of radially-migrating neurons in the mammalian cerebral cortex
  19. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis
  20. Plasma proteomic analysis of zebrafish following spring viremia of carp virus infection
  21. Prenatal activity from thalamic neurons governs the emergence of functional cortical maps in mice
  22. Direct pathway neurons in mouse dorsolateral striatum in vivo receive stronger synaptic input than indirect pathway neurons
  23. The Megalocytivirus RBIV Induces Apoptosis and MHC Class I Presentation in Rock Bream (Oplegnathus fasciatus) Red Blood Cells
  24. The occurrence and dynamics of polychlorinated hydrocarbons in roe deer (Capreolus capreolus) in South-western Slovakia
  25. Distribution of GABAergic Neurons and VGluT1 and VGAT Immunoreactive Boutons in the Ferret (Mustela putorius) Piriform Cortex and Endopiriform Nucleus. Comparison With Visual Areas 17, 18 and 19
  26. Nurse’s A-Phase-Silicocarnotite Ceramic-Bone Tissue Interaction in a Rabbit Tibia Defect Model
  27. Pancreatic alpha-cell mass in the early-onset and advanced stage of a mouse model of experimental autoimmune diabetes
  28. Activity-dependent death of transient Cajal-Retzius neurons is required for functional cortical wiring
  29. The peripheral eye: A neurogenic area with potential to treat retinal pathologies?
  30. Using Drosophila Models and Tools to Understand the Mechanisms of Novel Human Cancer Driver Gene Function
  31. Loss of Cntnap2 Causes Axonal Excitability Deficits, Developmental Delay in Cortical Myelination, and Abnormal Stereotyped Motor Behavior
  32. Correlated response to selection for litter size environmental variability in rabbits’ resilience
  33. IFIT5 Participates in the Antiviral Mechanisms of Rainbow Trout Red Blood Cells
  34. Double Drug Delivery Using Capped Mesoporous Silica Microparticles for the Effective Treatment of Inflammatory Bowel Disease
  35. Expression of the cold thermoreceptor TRPM8 in rodent brain thermoregulatory circuits
  36. Effect of stress on somatic cell count and milk yield and composition in goats
  37. Improved hemodynamic and liver function in portal hypertensive cirrhotic rats after administration of B. pseudocatenulatum CECT 7765
  38. Integrated Transcriptomic and Proteomic Analysis of Red Blood Cells from Rainbow Trout Challenged with VHSV Point Towards Novel Immunomodulant Targets
  39. The calmodulin-binding tetraleucine motif of KCNE4 is responsible for association with Kv1.3
  40. Fish Red Blood Cells Modulate Immune Genes in Response to Bacterial Inclusion Bodies Made of TNFa and a G-VHSV Fragment
  41. Litter Survival Differences between Divergently Selected Lines for Environmental Sensitivity in Rabbits
  42. Rainbow Trout Red Blood Cells Exposed to Viral Hemorrhagic Septicemia Virus Up-Regulate Antigen-Processing Mechanisms and MHC I&II, CD86, and CD83 Antigen-presenting Cell Markers
  43. Slow-Wave Activity in the S1HL Cortex Is Contributed by Different Layer-Specific Field Potential Sources during Development
  44. Correlated response in body condition and energy mobilisation in rabbits selected for litter size variability
  45. Microstructural White Matter Alterations in Men With Alcohol Use Disorder and Rats With Excessive Alcohol Consumption During Early Abstinence
  46. Unveiling introgression in bumblebee (Bombus terrestris) populations through mitogenome-based markers
  47. Gender differences in the effects of cannabidiol on ethanol binge drinking in mice
  48. Impact of Different Titanium Implant Thread Designs on Bone Healing: A Biomechanical and Histometric Study with an Animal Model
  49. 1-(2′,5′-Dihydroxyphenyl)-3-(2-fluoro-4-hydroxyphenyl)-1-propanone (RGM079): A Positive Allosteric Modulator of a7 Nicotinic Receptors with Analgesic and Neuroprotective Activity
  50. In utero exposure to bisphenol-A disrupts key elements of retinoid system in male mice offspring
  51. Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb
  52. TherMouseDuino: An affordable Open-Source temperature control system for functional magnetic resonance imaging experimentation with mice
  53. The Epigenetic Factor CBP Is Required for the Differentiation and Function of Medial Ganglionic Eminence-Derived Interneurons
  54. Potential Role of Rainbow Trout Erythrocytes as Mediators in the Immune Response Induced by a DNA Vaccine in Fish
  55. Comparison between diffusion MRI tractography and histological tract-tracing of cortico-cortical structural connectivity in the ferret brain
  56. Location and Plasticity of the Sodium Spike Initiation Zone in Nociceptive Terminals In Vivo
  57. Biomechanical and Histological Analysis of Titanium (Machined and Treated Surface) Versus Zirconia Implant Materials: An In Vivo Animal Study
  58. Effects of corneal injury on ciliary nerve fibre activity and corneal nociception in mice: A behavioural and electrophysiological study
  59. Transcranial direct-current stimulation (tDCS) improves detection of simple bright stimuli by amblyopic Long Evans rats in the SLAG task and produces an increase of parvoalbumin labelled cells in visual cortices
  60. A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA(1)), UCM-05194, Shows Efficacy in Neuropathic Pain Amelioration
  61. Multiple sclerosis drug FTY-720 toxicity is mediated by the heterotypic fusion of organelles in neuroendocrine cells
  62. Decreased circulating ErbB4 ectodomain fragments as a read-out of impaired signaling function in amyotrophic lateral sclerosis
  63. Synaptic mechanisms underlying the intense firing of neocortical layer 5B pyramidal neurons in response to cortico-cortical inputs
  64. Copper-dependent hydrolysis of trichloronate by turkey serum studied with use of new analytical procedure based on application of chiral chromatography and UV/Vis spectrophotometry
  65. The metabolic and vascular protective effects of olive (Olea europaea L.) leaf extract in diet-induced obesity in mice are related to the amelioration of gut microbiota dysbiosis and to its immunomodulatory properties
  66. Ancient mitogenomics clarifies radiation of extinct Mascarene giant tortoises (Cylindraspis spp.)
  67. Gene delivery to the rat retina by non-viral vectors based on chloroquine-containing cationic niosomes
  68. Preclinical Evaluation of the Antimicrobial-Immunomodulatory Dual Action of Xenohormetic Molecules against Haemophilus influenzae Respiratory Infection
  69. A Chronic Ocular-Hypertensive Rat Model induced by Injection of the Sclerosant Agent Polidocanol in the Aqueous Humor Outflow Pathway
  70. Single versus double experimental bile duct ligation model for inducing bacterial translocation
  71. Cortistatin regulates glucose-induced electrical activity and insulin secretion in mouse pancreatic beta-cells
  72. Influence of Olive Extracts on the Expression of Genes Involved in Lipid Metabolism in Medaka Fish
  73. Different behavior of polyphenols in energy metabolism of lipopolysaccharide-stimulated cells
  74. The prebiotic properties of Hibiscus sabdariffa extract contribute to the beneficial effects in diet-induced obesity in mice
  75. Bisphenol A Regulates Sodium Ramp Currents in Mouse Dorsal Root Ganglion Neurons and Increases Nociception
  76. Selective neuronal death following exposure to methylenedioxypyrovalerone is accompanied by an inhibition of NMDA receptor NR2B subunit expression
  77. Comparative study of extracellular recording methods for analysis of afferent sensory information: Empirical modeling, data analysis and interpretation
  78. Non-viral vectors based on cationic niosomes and minicircle DNA technology enhance gene delivery efficiency for biomedical applications in retinal disorders
  79. Impact on intestinal permeability of pediatric hyperosmolar formulations after dilution: Studies with rat perfusion method
  80. Ion-pair approach coupled with nanoparticle formation to increase bioavailability of a low permeability charged drug
Producción científica del curso académico 2018/2019
  1. The centrosome protein AKNA regulates neurogenesis via microtubule organization
  2. Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models
  3. Rag1 immunodeficiency-induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidative stress
  4. Regulatory T Cells Restrict Permeability to Bacterial Antigen Translocation and Preserve Short-Chain Fatty Acids in Experimental Cirrhosis
  5. Prenatal activity from thalamic neurons governs the emergence of functional cortical maps in mice
  6. Timing of Exposure and Bisphenol-A: Implications for Diabetes Development
  7. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis
  8. FXR modulates the gut-vascular barrier by regulating the entry sites for bacterial translocation in experimental cirrhosis
  9. Effects of corneal injury on ciliary nerve fibre activity and corneal nociception in mice: A behavioural and electrophysiological study
  10. CBP and SRF co-regulate dendritic growth and synaptic maturation
  11. Effect of stress on somatic cell count and milk yield and composition in goats
  12. The Immunosuppressant Macrolide Tacrolimus Activates Cold-Sensing TRPM8 Channels
  13. Cannabidiol regulates the expression of hypothalamus-pituitary-adrenal axis-related genes in response to acute restraint stress
  14. Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits
  15. A Retino-retinal Projection Guided by Unc5c Emerged in Species with Retinal Waves
  16. O-hexyl O-2,5-dichlorophenyl phosphoramidate as a substrate for domestic and sea bird serum A-esterases: Hydrolysis levels, Cu(2+)- and Zn(2+)-dependence and stereoselectivity
  17. Pancreatic alpha-cell mass in the early-onset and advanced stage of a mouse model of experimental autoimmune diabetes
  18. Impact of Different Titanium Implant Thread Designs on Bone Healing: A Biomechanical and Histometric Study with an Animal Model
  19. Cannabidiol does not display drug abuse potential in mice behavior
  20. Distribution of GABAergic Neurons and VGluT1 and VGAT Immunoreactive Boutons in the Ferret (Mustela putorius) Piriform Cortex and Endopiriform Nucleus. Comparison With Visual Areas 17, 18 and 19
  21. Extensive branching of radially-migrating neurons in the mammalian cerebral cortex
  22. Rainbow Trout Red Blood Cells Exposed to Viral Hemorrhagic Septicemia Virus Up-Regulate Antigen-Processing Mechanisms and MHC I&II, CD86, and CD83 Antigen-presenting Cell Markers
  23. Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis
  24. The Amniote Oculomotor Complex
  25. CBP/p300 in brain development and plasticity: disentangling the KAT’s cradle
  26. Biomechanical and Histological Analysis of Titanium (Machined and Treated Surface) Versus Zirconia Implant Materials: An In Vivo Animal Study
  27. Decreased circulating ErbB4 ectodomain fragments as a read-out of impaired signaling function in amyotrophic lateral sclerosis
  28. Plasma proteomic analysis of zebrafish following spring viremia of carp virus infection
  29. Microstructural White Matter Alterations in Men With Alcohol Use Disorder and Rats With Excessive Alcohol Consumption During Early Abstinence
  30. The calmodulin-binding tetraleucine motif of KCNE4 is responsible for association with Kv1.3
  31. IFIT5 Participates in the Antiviral Mechanisms of Rainbow Trout Red Blood Cells
  32. Expression of the cold thermoreceptor TRPM8 in rodent brain thermoregulatory circuits
  33. The peripheral eye: A neurogenic area with potential to treat retinal pathologies?
  34. Determination of intestinal permeability using in situ perfusion model in rats: Challenges and advantages to BCS classification applied to digoxin
  35. In utero exposure to bisphenol-A disrupts key elements of retinoid system in male mice offspring
  36. The Epigenetic Factor CBP Is Required for the Differentiation and Function of Medial Ganglionic Eminence-Derived Interneurons
  37. Location and Plasticity of the Sodium Spike Initiation Zone in Nociceptive Terminals In Vivo
  38. Loss of Cntnap2 Causes Axonal Excitability Deficits, Developmental Delay in Cortical Myelination, and Abnormal Stereotyped Motor Behavior
  39. A 3D Convolutional Neural Network to Model Retinal Ganglion Cell’s Responses to Light Patterns in Mice
  40. 1-(2′,5′-Dihydroxyphenyl)-3-(2-fluoro-4-hydroxyphenyl)-1-propanone (RGM079): A Positive Allosteric Modulator of a7 Nicotinic Receptors with Analgesic and Neuroprotective Activity
  41. Improved hemodynamic and liver function in portal hypertensive cirrhotic rats after administration of B. pseudocatenulatum CECT 7765
  42. TherMouseDuino: An affordable Open-Source temperature control system for functional magnetic resonance imaging experimentation with mice
  43. Non-invasive MRI windows to neuroinflammation
  44. Fish Red Blood Cells Modulate Immune Genes in Response to Bacterial Inclusion Bodies Made of TNFa and a G-VHSV Fragment
  45. The occurrence and dynamics of polychlorinated hydrocarbons in roe deer (Capreolus capreolus) in South-western Slovakia
  46. Emerging evidence for the modulation of exocytosis by signalling lipids
  47. Turbot (Scophthalmus maximus) Nk-lysin induces protection against the pathogenic parasite Philasterides dicentrarchi via membrane disruption
  48. Correlated response in body condition and energy mobilisation in rabbits selected for litter size variability
  49. Transcranial direct-current stimulation (tDCS) improves detection of simple bright stimuli by amblyopic Long Evans rats in the SLAG task and produces an increase of parvoalbumin labelled cells in visual cortices
  50. Hydroxycholesterol binds and enhances the anti-viral activities of zebrafish monomeric c-reactive protein isoforms
  51. Potential Role of Rainbow Trout Erythrocytes as Mediators in the Immune Response Induced by a DNA Vaccine in Fish
  52. Microgrooves and Microrugosities in Titanium Implant Surfaces: An In Vitro and In Vivo Evaluation
  53. Litter Survival Differences between Divergently Selected Lines for Environmental Sensitivity in Rabbits
  54. Rainbow Trout Erythrocytes ex vivo Transfection With a DNA Vaccine Encoding VHSV Glycoprotein G Induces an Antiviral Immune Response
  55. Double Drug Delivery Using Capped Mesoporous Silica Microparticles for the Effective Treatment of Inflammatory Bowel Disease
  56. Integrated Transcriptomic and Proteomic Analysis of Red Blood Cells from Rainbow Trout Challenged with VHSV Point Towards Novel Immunomodulant Targets
  57. Chromatin immunoprecipitation and high throughput sequencing of SVCV-infected zebrafish reveals novel epigenetic histone methylation patterns involved in antiviral immune response
  58. Using Drosophila Models and Tools to Understand the Mechanisms of Novel Human Cancer Driver Gene Function
  59. Correlated response to selection for litter size environmental variability in rabbits’ resilience
  60. The caudo-ventral pallium is a novel pallial domain expressing Gdf10 and generating Ebf3-positive neurons of the medial amygdala
  61. Pharmacological regulation of cannabinoid CB2 receptor modulates the reinforcing and motivational actions of ethanol
  62. Influence of hydroxyapatite granule size, porosity, and crystallinity on tissue reaction in vivo. Part B: a comparative study with biphasic synthetic biomaterials
  63. Gender differences in the effects of cannabidiol on ethanol binge drinking in mice
  64. Demineralized Bone Matrix Coating Si-Ca-P Ceramic Does Not Improve the Osseointegration of the Scaffold
  65. Copper-dependent hydrolysis of trichloronate by turkey serum studied with use of new analytical procedure based on application of chiral chromatography and UV/Vis spectrophotometry
  66. The Megalocytivirus RBIV Induces Apoptosis and MHC Class I Presentation in Rock Bream (Oplegnathus fasciatus) Red Blood Cells
  67. Synaptic mechanisms underlying the intense firing of neocortical layer 5B pyramidal neurons in response to cortico-cortical inputs
  68. Gene delivery to the rat retina by non-viral vectors based on chloroquine-containing cationic niosomes
  69. Bisphenol A Regulates Sodium Ramp Currents in Mouse Dorsal Root Ganglion Neurons and Increases Nociception
  70. Cortistatin regulates glucose-induced electrical activity and insulin secretion in mouse pancreatic beta-cells
  71. Deletion of Dlk1 increases the vulnerability to developing anxiety-like behaviors and ethanol consumption in mice
  72. A Chronic Ocular-Hypertensive Rat Model induced by Injection of the Sclerosant Agent Polidocanol in the Aqueous Humor Outflow Pathway
  73. Selective neuronal death following exposure to methylenedioxypyrovalerone is accompanied by an inhibition of NMDA receptor NR2B subunit expression
  74. Influence of Olive Extracts on the Expression of Genes Involved in Lipid Metabolism in Medaka Fish
  75. Gene transfer to rat cerebral cortex mediated by polysorbate 80 and poloxamer 188 nonionic surfactant vesicles
  76. Single versus double experimental bile duct ligation model for inducing bacterial translocation
  77. Non-viral vectors based on cationic niosomes as efficient gene delivery vehicles to central nervous system cells into the brain
  78. Polysorbate 20 non-ionic surfactant enhances retinal gene delivery efficiency of cationic niosomes after intravitreal and subretinal administration
  79. Complex hybridization patterns in European pond turtles (Emys orbicularis) in the Pyrenean Region
  80. Non-viral vectors based on cationic niosomes and minicircle DNA technology enhance gene delivery efficiency for biomedical applications in retinal disorders
  81. Different behavior of polyphenols in energy metabolism of lipopolysaccharide-stimulated cells
  82. Impact on intestinal permeability of pediatric hyperosmolar formulations after dilution: Studies with rat perfusion method
  83. Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs
  84. Multiscale dynamics of interstimulus interval integration in visual cortex
  85. Comparative study of extracellular recording methods for analysis of afferent sensory information: Empirical modeling, data analysis and interpretation
  86. Ion-pair approach coupled with nanoparticle formation to increase bioavailability of a low permeability charged drug
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Ética e Integridad en la Investigación
Código de Buenas Prácticas Científicas
Acuerdo de transparencia sobre el uso de animales en investigación
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