[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”3_4,1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”3_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text admin_label=”Introducci\u00f3n” _builder_version=”4.17.4″ global_colors_info=”{}”]<\/p>\n
Introducci\u00f3n<\/strong><\/h3>\nLa UMH est\u00e1 comprometida con la transparencia en experimentaci\u00f3n animal y por ello se adhiri\u00f3 al Acuerdo de transparencia sobre el uso de animales en experimentaci\u00f3n cient\u00edfica en Espa\u00f1a (abre en pesta\u00f1a nueva)<\/a><\/em> promovido por COSCE. M\u00e1s informaci\u00f3n en https:\/\/cosce.org\/acuerdo-de-transparencia\/<\/a><\/p>\nA continuaci\u00f3n, podr\u00e1 encontrar la Declaraci\u00f3n institucional de transparencia de la UMH sobre el uso de animales en investigaci\u00f3n (abre en pesta\u00f1a nueva).<\/a><\/p>\n![\"Acuerdo](\"https:\/\/rri.umh.es\/files\/2025\/01\/POSTER_ACUERDO_DE_TRANSPARENCIA-724x1024.jpg\")
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[\/et_pb_text][et_pb_text admin_label=”Divulgaci\u00f3n” _builder_version=”4.17.4″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
Divulgaci\u00f3n, formaci\u00f3n y promoci\u00f3n de las 3R (UMH y externas)<\/strong><\/h3>\n\n- Actividades realizadas en 2026 (abre en pesta\u00f1a nueva)<\/a><\/li>\n
- Actividades realizadas en 2025 (abre en pesta\u00f1a nueva)<\/a><\/li>\n
- Actividades realizadas en 2024 (abre en pesta\u00f1a nueva)<\/a><\/li>\n
- Actividades realizadas en 2023 (abre en pesta\u00f1a nueva)<\/a><\/li>\n
- Actividades realizadas en 2022 (abre en pesta\u00f1a nueva)<\/a><\/li>\n
- Actividades realizadas en 2021 (abre en pesta\u00f1a nueva)<\/a><\/li>\n
- Actividades realizadas en 2020 (abre en pesta\u00f1a nueva)<\/a><\/li>\n
- Actividades realizadas en 2019 (abre en pesta\u00f1a nueva)<\/a><\/li>\n
- Actividades realizadas en el curso acad\u00e9mico 2018\/19 (abre en pesta\u00f1a nueva)<\/a><\/li>\n
- Actividades realizadas en el curso acad\u00e9mico 2017\/18 (abre en pesta\u00f1a nueva)<\/a><\/li>\n
- Actividades realizadas en el curso acad\u00e9mico 2016\/17 (abre en pesta\u00f1a nueva)<\/a><\/li>\n<\/ul>\n
[\/et_pb_text][et_pb_text admin_label=”Informes Hamelin” _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n
Informes sobre el uso de animales con fines cient\u00edficos en la UMH<\/strong><\/h3>\n\n- Transparencia en el uso de animales en investigaci\u00f3n en la UMH, a\u00f1o 2024<\/strong> (abre en pesta\u00f1a nueva)<\/a><\/li>\n
- Transparencia en el uso de animales en investigaci\u00f3n en la UMH, a\u00f1o 2023<\/strong> (abre en pesta\u00f1a nueva)<\/a><\/li>\n
- Transparencia en el uso de animales en investigaci\u00f3n en la UMH, a\u00f1o 2022<\/strong> (abre en pesta\u00f1a nueva)<\/a><\/li>\n
- Transparencia en el uso de animales en investigaci\u00f3n en la UMH, a\u00f1o 2021<\/strong> (abre en pesta\u00f1a nueva)<\/a><\/li>\n
- Transparencia en el uso de animales en investigaci\u00f3n en la UMH, a\u00f1o 2020<\/strong> (abre en pesta\u00f1a nueva)<\/a><\/li>\n
- Transparencia en el uso de animales en investigaci\u00f3n en la UMH, a\u00f1o 2019<\/strong> (abre en pesta\u00f1a nueva)<\/a><\/li>\n
- Transparencia en el uso de animales en investigaci\u00f3n en la UMH, curso acad\u00e9mico 2017-18<\/strong> (abre en pesta\u00f1a nueva)<\/a><\/li>\n<\/ul>\n
[\/et_pb_text][et_pb_cta title=”M\u00e9todos Alternativos en Investigaci\u00f3n Biom\u00e9dica” button_url=”https:\/\/joint-research-centre.ec.europa.eu\/reference-measurement\/european-union-reference-laboratories\/eu-reference-laboratory-alternatives-animal-testing-eurl-ecvam\/biomedical-research_en” url_new_window=”on” button_text=”Click aqu\u00ed para descubrirlos” title_tablet=”M\u00e1s informaci\u00f3n sobre M\u00e9todos alternativos” title_phone=”M\u00e1s informaci\u00f3n sobre M\u00e9todos alternativos” title_last_edited=”on|desktop” admin_label=”M\u00e9todos alternativos” _builder_version=”4.17.4″ _module_preset=”default” header_font=”|700|||||||” header_text_color=”#009368″ body_text_align=”justify” body_text_color=”#000000″ background_color=”RGBA(255,255,255,0)” text_orientation=”justified” background_layout=”light” animation_style=”slide” border_radii=”on|10px|10px|10px|10px” border_width_all=”5px” border_color_all=”#000000″ global_colors_info=”{}” title__hover_enabled=”on|hover” title__hover=”Informaci\u00f3n sobre M\u00e9todos Alternativos No-animales”]<\/p>\n
Revisi\u00f3n de modelos no animales avanzados en investigaci\u00f3n biom\u00e9dica<\/strong><\/h4>\nLa EURL ECVAM<\/a> ha puesto en marcha una serie de estudios para revisar los modelos no animales disponibles y emergentes que se est\u00e1n utilizando para la investigaci\u00f3n en siete \u00e1reas de enfermedades:<\/p>\n\n- enfermedades del tracto respiratorio<\/a><\/li>\n
- c\u00e1ncer de mama<\/a><\/li>\n
- trastornos neurodegenerativos<\/a><\/li>\n
- inmuno-oncolog\u00eda<\/a><\/li>\n
- pruebas de inmunogenicidad de medicamentos avanzados<\/a><\/li>\n
- enfermedades cardiovasculares<\/a><\/li>\n
- enfermedades autoinmunes<\/a><\/li>\n<\/ul>\n
El objetivo<\/strong> es identificar y describir contextos de investigaci\u00f3n espec\u00edficos en los que se han dejado de lado los modelos animales en favor de t\u00e9cnicas novedosas sin animales que utilizan, por ejemplo, m\u00e9todos in vitro basados en c\u00e9lulas humanas y tejidos artificiales o enfoques in silico que emplean la modelizaci\u00f3n y la simulaci\u00f3n por ordenador.<\/p>\nSe espera que la comprensi\u00f3n y el intercambio de informaci\u00f3n sobre casos de \u00e9xito en el uso de modelos alternativos en la investigaci\u00f3n biom\u00e9dica faciliten y aceleren la transici\u00f3n hacia planteamientos sin animales<\/strong>.<\/p>\n[\/et_pb_cta][et_pb_text admin_label=”Avances en investigaci\u00f3n biom\u00e9dica gracias al uso de animales: producci\u00f3n cient\u00edfica” _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n
Avances en investigaci\u00f3n biom\u00e9dica gracias al uso de animales: producci\u00f3n cient\u00edfica<\/strong><\/h3>\n[\/et_pb_text][et_pb_toggle title=”Producci\u00f3n cient\u00edfica del a\u00f1o 2024″ admin_label=”Producci\u00f3n cient\u00edfica 2024″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n
\n- SUCNR1 regulates insulin secretion and glucose elevates the succinate response in people with prediabetes<\/a><\/li>\n
- Multiple parallel cell lineages in the developing mammalian cerebral cortex<\/a><\/li>\n
- Gene regulatory landscape of cerebral cortex folding<\/a><\/li>\n
- SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer<\/a><\/li>\n
- A multiomic atlas of the aging hippocampus reveals molecular changes in response to environmental enrichment<\/a><\/li>\n
- The ion channel TRPM8 is a direct target of the immunosuppressant rapamycin in primary sensory neurons<\/a><\/li>\n
- Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in Kras(G12D)-driven tumors<\/a><\/li>\n
- Kainate receptors regulate synaptic integrity and plasticity by forming a complex with synaptic organizers in the cerebellum<\/a><\/li>\n
- Overlapping role of synaptophysin and synaptogyrin family proteins in determining the small size of synaptic vesicles<\/a><\/li>\n
- Essential role of p21(Waf1\/Cip1) in the modulation of post-traumatic hippocampal Neural Stem Cells response<\/a><\/li>\n
- ARID1A-BAF coordinates ZIC2 genomic occupancy for epithelial-to-mesenchymal transition in cranial neural crest specification<\/a><\/li>\n
- Development of an efficient NUPR1 inhibitor with anticancer activity<\/a><\/li>\n
- Piezo2 channels and tactile pain: an intriguing voltage connection<\/a><\/li>\n
- 2-iodohexadecanal induces autophagy during goiter involution<\/a><\/li>\n
- OCaR1 endows exocytic vesicles with autoregulatory competence by preventing uncontrolled Ca2+ release, exocytosis, and pancreatic tissue damage<\/a><\/li>\n
- Transplantation of dorsal root ganglia overexpressing the NaChBac sodium channel improves locomotion after complete SCI<\/a><\/li>\n
- Nrg1 intracellular signaling regulates the development of interhemispheric callosal axons in mice<\/a><\/li>\n
- Disruption of the autism-associated Pcdh9 gene leads to transcriptional alterations, synapse overgrowth, and defective network activity in the CA1<\/a><\/li>\n
- Cirrhosis-downregulated LSECtin can be retrieved by cytokines, shifts the TLR-induced LSECs secretome and correlates with the hepatic Th response<\/a><\/li>\n
- Concentration of selected biogenic and risk elements in liver, kidneys and muscle of domestic rabbit and wild brown hare<\/a><\/li>\n
- Fetal Cannabinoid Syndrome: Behavioral and Brain Alterations of the Offspring Exposed to Dronabinol during Gestation and Lactation<\/a><\/li>\n
- Aging Deteriorates Blood Brain Barrier Function and Polarizes Adaptive T Cell Expansion Contributing to Neurocognitive Damage in Experimental Cirrhosis<\/a><\/li>\n
- Preclinical Experimental Study on New Cervical Implant Design to Improve Peri-Implant Tissue Healing<\/a><\/li>\n
- Hyperglucagonemia and glucagon hypersecretion in early type 2 diabetes result from multifaceted dysregulation of pancreatic mouse \u03b1-cells<\/a><\/li>\n
- CXCL12 promotes the crossing of retinal ganglion cell axons at the optic chiasm<\/a><\/li>\n
- Identification of Antimicrobial-Resistant Zoonotic Bacteria in Swine Production: Implications from the One Health Perspective<\/a><\/li>\n
- Adolescent intermittent ethanol exposure decreases perineuronal nets in the hippocampus in a sex dependent manner: Modulation through pharmacological inhibition of RPTP\u03b2\/\u03b6<\/a><\/li>\n
- A single dose of cocaine rewires the 3D genome structure of midbrain dopamine neurons<\/a><\/li>\n
- Microdissection and Single-Cell Suspension of Neocortical Layers From Ferret Brain for Single-Cell Assays<\/a><\/li>\n
- Mouse cortical organoids reveal key functions of p73 isoforms: TAp73 governs the establishment of the archetypical ventricular-like zones while DNp73 is central in the regulation of neural cell fate<\/a><\/li>\n
- In Vivo Predictive Dissolution and Biopharmaceutic-Based In Silico Model to Explain Bioequivalence Results of Valsartan, a Biopharmaceutics Classification System Class IV Drug<\/a><\/li>\n
- Self-experience of a negative event alters responses to others in similar states through prefrontal cortex CRF mechanisms<\/a><\/li>\n
- Ocular surface information seen from the somatosensory thalamus and cortex<\/a><\/li>\n
- Endoplasmic reticulum stress triggers unfolded protein response as an antiviral strategy of teleost erythrocytes<\/a><\/li>\n
- Additive antinociceptive action of intrathecal anandamide reuptake inhibitor and morphine in the management of post-incisional pain in rats<\/a><\/li>\n
- Enhancing In Vivo Electroporation Efficiency through Hyaluronidase: Insights into Plasmid Distribution and Optimization Strategies<\/a><\/li>\n
- Proper Frequency of Perinatal Retinal Waves Is Essential for the Precise Wiring of Visual Axons in Nonimage-Forming Nuclei<\/a><\/li>\n
- FrozONE: quick cell nucleus enrichment for comprehensive proteomics analysis of frozen tissues<\/a><\/li>\n
- Specific targeting of the NRF2\/\u03b2-TrCP axis promotes beneficial effects in NASH<\/a><\/li>\n
- Cytomegalovirus infection of the fetal brain: intake of aspirin during pregnancy blunts neurodevelopmental pathogenesis in the offspring<\/a><\/li>\n
- Pharmaceutical Compounding in Veterinary Medicine: Suspension of Itraconazole<\/a><\/li>\n
- Factors affecting N-acetyl-\u03b2-D-glucosaminidase as an indicator for mastitis detection in dairy sheep<\/a><\/li>\n<\/ol>\n
[\/et_pb_toggle][et_pb_toggle title=”Producci\u00f3n cient\u00edfica del a\u00f1o 2023″ admin_label=”Producci\u00f3n cient\u00edfica 2023″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n
\n- Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum suppresses interaction with familiar mice<\/a><\/li>\n
- TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy<\/a><\/li>\n
- Building thalamic neuronal networks during mouse development<\/a><\/li>\n
- Cognitive Alterations in Addictive Disorders: A Translational Approach<\/a><\/li>\n
- Role of TMEM100 in mechanically insensitive nociceptor un-silencing<\/a><\/li>\n
- Cannabidiol regulates behavioral and brain alterations induced by spontaneous alcohol withdrawal<\/a><\/li>\n
- Methods to Identify Cognitive Alterations from Animals to Humans: A Translational Approach<\/a><\/li>\n
- Cannabidiol repairs behavioral and brain disturbances in a model of fetal alcohol spectrum disorder<\/a><\/li>\n
- SARM1 detection in myelinating glia: sarm1\/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice<\/a><\/li>\n
- Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models<\/a><\/li>\n
- A method for multiple sampling mouse sperm in vivo\u2020<\/a><\/li>\n
- MRI texture-based radiomics analysis for the identification of altered functional networks in alcoholic patients and animal models<\/a><\/li>\n
- Long-Term Feeding of Dairy Goats with 40% Artichoke by-Product Silage Preserves Milk Yield, Nutritional Composition and Animal Health Status<\/a><\/li>\n
- Monitoring Fine and Associative Motor Learning in Mice Using the Erasmus Ladder<\/a><\/li>\n
- The outcome of boosting mitochondrial activity in alcohol-associated liver disease is organ-dependent<\/a><\/li>\n
- The Contribution of TRPA1 to Corneal Thermosensitivity and Blink Regulation in Young and Aged Mice<\/a><\/li>\n
- Mesoscale calcium imaging in vivo: evolution and contribution to developmental neuroscience<\/a><\/li>\n
- Cyclosporine A Decreases Dryness-Induced Hyperexcitability of Corneal Cold-Sensitive Nerve Terminals<\/a><\/li>\n
- Saturated fatty acid-enriched small extracellular vesicles mediate a crosstalk inducing liver inflammation and hepatocyte insulin resistance<\/a><\/li>\n
- Regulation of Cortico-Thalamic JNK1\/2 and ERK1\/2 MAPKs and Apoptosis-Related Signaling Pathways in PDYN Gene-Deficient Mice Following Acute and Chronic Mild Stress<\/a><\/li>\n
- Optimal Parameters to Milk Murciano-Granadina Goats in Mid and Low-Line Milking Parlours<\/a><\/li>\n
- MAPK\/MAK\/MRK overlapping kinase (MOK) controls microglial inflammatory\/type-I IFN responses via Brd4 and is involved in ALS<\/a><\/li>\n
- FGF signaling promotes spreading of fat body precursors necessary for adult adipogenesis in Drosophila<\/a><\/li>\n
- Unveiling behavioral and molecular neuroadaptations related to the antidepressant action of cannabidiol in the unpredictable chronic mild stress model<\/a><\/li>\n
- Cell-specific vulnerability to metabolic failure: the crucial role of parvalbumin expressing neurons in creatine transporter deficiency<\/a><\/li>\n
- Genetic and Phenotypic Parameters of Rabbit Individual Body Weight in the Preweaning Period<\/a><\/li>\n
- Did the Addition of Olive Cakes Obtained by Different Methods of Oil Extraction in the Finishing Diet of B\u00edsaro Pigs Affect the Volatile Compounds and Sensory Characteristics of Dry-Cured Loin and \\”Cacha\u00e7o\\”?<\/a><\/li>\n
- Natural and Pathological Aging Distinctively Impacts the Pheromone Detection System and Social Behavior<\/a><\/li>\n
- Impact of inclusion of post-spermatic ejaculate fraction in boar seminal doses on sperm metabolism, quality, and interaction with uterine fluid<\/a><\/li>\n
- Neuronal Cannabinoid CB(1) Receptors Suppress the Growth of Melanoma Brain Metastases by Inhibiting Glutamatergic Signalling<\/a><\/li>\n
- Changes in Body Reserves, Non-Esterified Fatty Acids, and Leptin during the Reproductive Lifespan of the Rabbit Female<\/a><\/li>\n
- Structural basis of envelope and phase intrinsic coupling modes in the cerebral cortex<\/a><\/li>\n
- ReadEDTest: A tool to assess the readiness of in vitro test methods under development for identifying endocrine disruptors<\/a><\/li>\n
- Increased alpha-synuclein and neuroinflammation in the substantia nigra triggered by systemic inflammation are reversed by targeted inhibition of the receptor for advanced glycation end products (RAGE)<\/a><\/li>\n
- Effect of the Onset of Intramammary Infection on the Electrical Conductivity of Ewe’s Milk and Study of Various Algorithms for Its On-Line Detection<\/a><\/li>\n
- Deep-brain stimulation of the human nucleus accumbens-medial septum enhances memory formation<\/a><\/li>\n
- Lipid peroxidation and liver damage in double and simple common bile duct ligation models in male Sprague-Dawley rats<\/a><\/li>\n
- Effect of environmental variance-based resilience selection on the gut metabolome of rabbits<\/a><\/li>\n
- Selection for environmental variance shifted the gut microbiome composition driving animal resilience<\/a><\/li>\n
- Umbilical cord mesenchymal stromal cells transplantation delays the onset of hyperglycemia in the RIP-B7.1 mouse model of experimental autoimmune diabetes through multiple immunosuppressive and anti-inflammatory responses<\/a><\/li>\n
- Modulation of Caecal Microbiota and Metabolome Profile in Salmonella-Infected Broilers by Phage Therapy<\/a><\/li>\n
- Long-term biophysical stability of nanodiamonds combined with lipid nanocarriers for non-viral gene delivery to the retina<\/a><\/li>\n
A continuaci\u00f3n, podr\u00e1 encontrar la Declaraci\u00f3n institucional de transparencia de la UMH sobre el uso de animales en investigaci\u00f3n (abre en pesta\u00f1a nueva).<\/a><\/p>\n [\/et_pb_text][et_pb_text admin_label=”Divulgaci\u00f3n” _builder_version=”4.17.4″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n [\/et_pb_text][et_pb_text admin_label=”Informes Hamelin” _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_cta title=”M\u00e9todos Alternativos en Investigaci\u00f3n Biom\u00e9dica” button_url=”https:\/\/joint-research-centre.ec.europa.eu\/reference-measurement\/european-union-reference-laboratories\/eu-reference-laboratory-alternatives-animal-testing-eurl-ecvam\/biomedical-research_en” url_new_window=”on” button_text=”Click aqu\u00ed para descubrirlos” title_tablet=”M\u00e1s informaci\u00f3n sobre M\u00e9todos alternativos” title_phone=”M\u00e1s informaci\u00f3n sobre M\u00e9todos alternativos” title_last_edited=”on|desktop” admin_label=”M\u00e9todos alternativos” _builder_version=”4.17.4″ _module_preset=”default” header_font=”|700|||||||” header_text_color=”#009368″ body_text_align=”justify” body_text_color=”#000000″ background_color=”RGBA(255,255,255,0)” text_orientation=”justified” background_layout=”light” animation_style=”slide” border_radii=”on|10px|10px|10px|10px” border_width_all=”5px” border_color_all=”#000000″ global_colors_info=”{}” title__hover_enabled=”on|hover” title__hover=”Informaci\u00f3n sobre M\u00e9todos Alternativos No-animales”]<\/p>\n La EURL ECVAM<\/a> ha puesto en marcha una serie de estudios para revisar los modelos no animales disponibles y emergentes que se est\u00e1n utilizando para la investigaci\u00f3n en siete \u00e1reas de enfermedades:<\/p>\n El objetivo<\/strong> es identificar y describir contextos de investigaci\u00f3n espec\u00edficos en los que se han dejado de lado los modelos animales en favor de t\u00e9cnicas novedosas sin animales que utilizan, por ejemplo, m\u00e9todos in vitro basados en c\u00e9lulas humanas y tejidos artificiales o enfoques in silico que emplean la modelizaci\u00f3n y la simulaci\u00f3n por ordenador.<\/p>\n Se espera que la comprensi\u00f3n y el intercambio de informaci\u00f3n sobre casos de \u00e9xito en el uso de modelos alternativos en la investigaci\u00f3n biom\u00e9dica faciliten y aceleren la transici\u00f3n hacia planteamientos sin animales<\/strong>.<\/p>\n [\/et_pb_cta][et_pb_text admin_label=”Avances en investigaci\u00f3n biom\u00e9dica gracias al uso de animales: producci\u00f3n cient\u00edfica” _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_toggle title=”Producci\u00f3n cient\u00edfica del a\u00f1o 2024″ admin_label=”Producci\u00f3n cient\u00edfica 2024″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n [\/et_pb_toggle][et_pb_toggle title=”Producci\u00f3n cient\u00edfica del a\u00f1o 2023″ admin_label=”Producci\u00f3n cient\u00edfica 2023″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n<\/p>\nDivulgaci\u00f3n, formaci\u00f3n y promoci\u00f3n de las 3R (UMH y externas)<\/strong><\/h3>\n
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Informes sobre el uso de animales con fines cient\u00edficos en la UMH<\/strong><\/h3>\n
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Revisi\u00f3n de modelos no animales avanzados en investigaci\u00f3n biom\u00e9dica<\/strong><\/h4>\n
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Avances en investigaci\u00f3n biom\u00e9dica gracias al uso de animales: producci\u00f3n cient\u00edfica<\/strong><\/h3>\n
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